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Prof. Dr. med. Dr. phil. Christine Bernsmeier

Leitende Ärztin Gastroenterologie/Hepatologie

 

Portrait
Portrait
Lebenslauf
Mitgliedschaften
Publikationen
Lebenslauf

2022
Titularprofessur der Universität Basel für Gastroenterologie, speziell Hepatologie

Seit 2021
Leitende Ärztin Hepatologie
Clarunis Universitäres Bauchzentrum Basel
Standort Universitätsspital Basel

Seit 2021
Forschungsgruppenleiterin am Departement Klinische Forschung der Universität Basel

Seit 2020
Forschungsgruppenleiterin «Translationale Hepatologie» am Departement Biomedizin der Universität Basel

2019-2020
Oberärztin Gastroenterologie/Hepatologie
Clarunis Universitäres Bauchzentrum Basel
Standort Universitätsspital Basel

3/2018-12/2018
Oberärztin, Gastroenterologie & Hepatologie
Universitätsspital Basel

2016
Venia docendi der Universität Basel (Habilitation in Gastroenterologie, speziell Hepatologie)

01/2015-02/2018
Oberärztin Gastroenterologie & Hepatologie
Schwerpunkt Hepatologie
Kantonsspital St. Gallen

2012-2014
Clinical Research Fellow, Liver Intensive Therapy Unit
King’s College Hospital, London, UK

2012-2014
EASL Sheila Sherlock Postdoctoral Fellowship, Institute of Liver Studies
King’s College London, UK (Prof. J. Wendon)

2013
Schwerpunkt Titel Hepatologie FMH

2012
Facharzttitel Gastroenterologie FMH

07/2010-11/2012
Assistenzärztin Gastroenterologie & Hepatologie
Universitätsspital Basel

01/2010-06/2010
Oberärztin Innere Medizin
Universitätsspital Basel

2010
Facharzttitel Innere Medizin FMH

04/2008-12/2009
Assistenzärztin Innere Medizin
Universitätsspital Basel

04/2005-03/2008
Wissenschaftliche Assistenzärztin Hepatologie
Universitätsspital Basel

04/2005-03/2008
Promotion in Zellbiologie (Dr. phil., PhD), Hepatologie Labor
Universitätsspital Basel, Schweiz (Prof. M.H. Heim)

08/2004-03/2005
Assistenzärztin Innere Medizin
Universitätsspital Basel

02/2003-07/2004
Assistenzärztin Innere Medizin und Gastroenterologie & Hepatologie
Universitätsklinikum Kiel, Deutschland

1999-2002
Promotion in Medizin (Dr. med., MD) Labor für Gastroenterologie
Universitätsklinikum Kiel, Deutschland (Prof. U.R. Fölsch)

2000-2002
Auslandsaufenthalte an den Universitäten Montpellier (F), Lyon (F) und Basel (CH)

1996-2002
Medizinstudium, Martin-Luther Universität Halle-Wittenberg und Christian-Albrechts Universität Kiel, Deutschland

 

Mitgliedschaften

Federatio Medicorum Helveticorum (FMH)

Deutsche Gesellschaft für Innere Medizin (DGIM)

Schweizerische Gesellschaft für Gastroenterologie (SGG)

European Association for the Study of the Liver (EASL)

Swiss Association for the Study of the Liver (SASL)

British Association for the Study of the Liver (BASL)

European Association for the Study of the Liver - Chronic Liver Failure Consortium (EASL-CLIF)

Publikationen
  • Roth S, Flint E, Ghataore L, Patel VC, Singanayagam A, Vincent RP, Triantafyllou E, Ma Y, Bernal W, Auzinger G, Heneghan M, Antoniades C, Christ-Crain M, McPhail MJW, Taylor DR, Wendon J, Bernsmeier C, Low baseline but not delta cortisol relates to 28-day transplant-free survival in acute and acute-on-chronic liver failure. Gastro Hep Advances. Jan 2023. 2(1):72-82. published Sep 03, 2022. DOI:https://doi.org/10.1016/j.gastha.2022.08.006
  • Trovato FM, Zia R, Artru F, Mujib S, Jerome E, Cavazza A, Coen M, Wilson I, Holmes E, Morgan P, Singanayagam A, Bernsmeier C, Napoli S, Bernal W, Wendon J, Miquel R, Menon K, Patel VC, Smith J, Atkinson SR, Triantafyllou E, McPhail MJ. Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure. J Hepatol. 2022 Nov 9:S0168-8278(22)03288-3. doi: 10.1016/j.jhep.2022.10.031.
  • Codoni G, Kirchner T, Engel B, Villamil AM, Efe C, Stättermayer AF, Weltzsch JP, Sebode M, Bernsmeier C, Lleo A, Gevers TJ, Kupčinskas L, Castiella A, Pinazo J, De Martin E, Bobis I, Sandahl TD, Pedica F, Invernizzi F, Del Poggio P, Bruns T, Kolev M, Semmo N, Bessone F, Giguet B, Poggi G, Ueno M, Jang H, Elpek GÖ, Soylu NK, Cerny A, Wedemeyer H, Vergani D, Mieli-Vergani G, Lucena MI, Andrade RJ, Zen Y, Taubert R, Terziroli Beretta-Piccoli B. Histological and serological features of acute liver injury after SARS-CoV-2 vaccination. JHEP Rep. 2022 Oct 13;5(1):100605. doi: 10.1016/j.jhepr.2022.100605.
  • Etienne S, Vosbeck J, Bernsmeier C, Osthoff M. Prevention of Hepatitis B Reactivation in Patients Receiving Immunosuppressive Therapy: a Case Series and Appraisal of Society Guidelines. J Gen Intern Med. 2022 Sep 22. doi: 10.1007/s11606-022-07806-9. Online ahead of print.
  • Guri Y, Vosbeck J, Dickenmann M, Jetter A, Bernsmeier C. Exacerbation of Familial Intrahepatic Cholestasis in Conjunction with COVID-19 Vaccination. J Hepatol. 2022 Sep;77(3):872-874. doi: 10.1016/j.jhep.2022.05.003.
  • Efe C, Kulkarni AV, Beretta-Piccoli BT, Magro B, Stättermayer AF, Cengiz M, Clayton-Chubb D, Lammert C, Bernsmeier C, Gül Ö, la Tijera FH, Anders M, Lytvyak E, Akın M, Purnak T, Liberal R, Peralta M, Ebik B, Duman S, Demir N, Balaban Y, Urzua Á, Contreras F, Venturelli MG, Bilgiç Y, Medina A, Girala M, Günşar F, Londoño MC, Androutsakos T, Kisch A, Yurci A, Güzelbult F, Çağın YF, Avcı E, Akyıldız M, Dindar-Demiray EK, Harputluoğlu M, Kumar R, Satapathy SK, Mendizabal M, Silva M, Fagiuoli S, Roberts SK, Soylu NK, Idilman R, Yoshida EM, Montano-Loza AJ, Dalekos GN, Ridruejo E, Schiano TD, Wahlin S. Liver injury after SARS-CoV-2 vaccination: Features of immune-mediated hepatitis, role of corticosteroid therapy and outcome. Hepatology. 2022 May 14. doi: 10.1002/hep.32572.
  • Geng A, Flint E and Bernsmeier C. Plasticity of monocytes and macrophages in cirrhosis of the liver. Front. Netw. Physiol. 2022. 2:937739. doi: 10.3389/fnetp.2022.937739
  • Flint E, Triantafyllou E, Bernsmeier C, TAM Receptors in the Pathophysiology of Liver Disease, Livers 2022; Livers 2022, 2(1), 15-29
  • Brenig R, Bernsmeier C, Diagnostik und Therapie der Leberzirrhose, GastroMAG 2022; 1:14-17
  • Roth S, Schmidt-Trucksäss A, Timper K, Bernsmeier C, Ernährung bei Leberzirrhose, Schw Z Ern Med, 2021; 4:10-13
  • Khamri W, Gudd C, Liu T, Nathwani R, Krasniqi M, Azam S, Barbera T, Trovato FM, Possamai L, Triantafyllou E, Seoane RC, Lebosse F, Singanayagam A, Kumar N, Bernsmeier C, Mukherjee S, McPhail M, Weston CJ, Antoniades CG, Thursz MR. Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis. Gut. 2021 Aug 3:gutjnl-2021-324071. doi: 10.1136/gutjnl-2021-324071.
  • Van der Merwe S, Chokshi S, Bernsmeier C, Albillos A. The multifactorial mechanisms of bacterial infection in decompensated cirrhosis. J Hepatol. 2021 Jul;75 Suppl 1:S82-S100. doi: 10.1016/j.jhep.2020.11.029.
  • Triantafyllou E, Gudd CLC, Mawhin MA, Husbyn HC, Trovato FM, Siggins MK, O'Connor T, Kudo H, Mukherjee SK, Wendon JA, Bernsmeier C, Goldin RD, Botto M, Khamri W, McPhail MJ, Possamai LA, Woollard KJ, Antoniades CG, Thursz MR. PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury. J Clin Invest. 2021 Feb 15;131(4):e140196. doi: 10.1172/JCI140196.
  • Ebrahimi F., Bernsmeier C. Häufige Lebererkrankungen – Früherkennung rettet Leben, Der Allgemeinarzt 2021; 18:4-7
  • Kronlage C, Hardmeier M, Bally S, Scholz MC, Bucher HC, Müller OK, Winterhalder C, Mongiat M, Müller J, Polymeris A, Weber M, Lausberg C, Kassi E, Kuhle J, Kappos L, Hermann W, Bernsmeier C, Yaldizli Ö. Muscle stiffness, gait instability, and liver cirrhosis in Wilson's disease. Lancet. 2020 Oct 3;396(10256):990.
  • Bernsmeier C, McPhail MJW. Editorial: outcome prediction in patients with cirrhosis and acute-on-chronic liver failure-authors' reply. Aliment Pharmacol Ther. 2020 Oct;52(7):1227-1228.
  • Bernsmeier C, Cavazza A, Fatourou EM, Theocharidou E, Akintimehin A, Baumgartner B, Dhar A, Auzinger G, Thursz M, Bernal W, Wendon JA, Karvellas CJ, Antoniades CG, McPhail MJW. Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure. Aliment Pharmacol Ther. 2020 Sep;52(5):855-865.
  • Bernsmeier C, van der Merwe S, Périanin A. Innate immune cells in cirrhosis. J Hepatol. 2020 Jul;73(1):186-201. doi: 10.1016/j.jhep.2020.03.027.
  • Keerl C, Bernsmeier C. [Elevated liver function tests - as incidental finding in general practice]. Ther Umsch. 2020;77(8):371-378.
  • Leuenberger AB, Bernsmeier C, Bingisser R, Mansella G, Akutes Leberversagen und hämolytische Anämie: Die junge ikterische Patientin. Swiss Med Forum. 2020; 20(1922):319-322
  • Ebrahimi F., Bernsmeier C. Häufige Lebererkrankungen – Diagnostik und Therapie. Leading Opinions Innere Medizin. 2020; 4:61-65
  • Triantafyllou E, Gudd CLC, Mawhin MA, Husbyn HC, Trovato FM, Siggins MK, O'Connor T, Kudo H, Mukherjee SK, Wendon JA, Bernsmeier C, Goldin RD, Botto M, Khamri W, McPhail MJ, Possamai LA, Woollard KJ, Antoniades CG, Thursz MR. PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury. J Clin Invest. 2021 Feb 15;131(4):e140196. doi: 10.1172/JCI140196.
  • Ebrahimi F., Bernsmeier C. Häufige Lebererkrankungen – Früherkennung rettet Leben, Der Allgemeinarzt 2021; 18:4-7
  • Kronlage C, Hardmeier M, Bally S, Scholz MC, Bucher HC, Müller OK, Winterhalder C, Mongiat M, Müller J, Polymeris A, Weber M, Lausberg C, Kassi E, Kuhle J, Kappos L, Hermann W, Bernsmeier C, Yaldizli Ö. Muscle stiffness, gait instability, and liver cirrhosis in Wilson's disease. Lancet. 2020 Oct 3;396(10256):990.
  • Bernsmeier C, McPhail MJW. Editorial: outcome prediction in patients with cirrhosis and acute-on-chronic liver failure-authors' reply. Aliment Pharmacol Ther. 2020 Oct;52(7):1227-1228.
  • Bernsmeier C, Cavazza A, Fatourou EM, Theocharidou E, Akintimehin A, Baumgartner B, Dhar A, Auzinger G, Thursz M, Bernal W, Wendon JA, Karvellas CJ, Antoniades CG, McPhail MJW. Leucocyte ratios are biomarkers of mortality in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure. Aliment Pharmacol Ther. 2020 Sep;52(5):855-865.
  • Bernsmeier C, van der Merwe S, Périanin A. Innate immune cells in cirrhosis. J Hepatol. 2020 Jul;73(1):186-201. doi: 10.1016/j.jhep.2020.03.027.
  • Keerl C, Bernsmeier C. [Elevated liver function tests - as incidental finding in general practice]. Ther Umsch. 2020;77(8):371-378.
  • Leuenberger AB, Bernsmeier C, Bingisser R, Mansella G, Akutes Leberversagen und hämolytische Anämie: Die junge ikterische Patientin. Swiss Med Forum. 2020; 20(1922):319-322
  • Ebrahimi F., Bernsmeier C. Häufige Lebererkrankungen – Diagnostik und Therapie. Leading Opinions Innere Medizin. 2020; 4:61-65
  • Brenig R, Pop OT, Triantafyllou E, Geng A, Singanayagam A, Perez-Shibayama C, Besse L, Cupovic J, Künzler P, Boldanova T, Brand S, Semela D, Duong FH, Weston CJ, Ludewig B, Heim MH, Wendon J, Antoniades CG, Bernsmeier C. Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis. Life Sci Alliance. 2019 Dec 10;3(1). pii: e201900465. doi: 10.26508/lsa.201900465. Print 2020 Jan.
  • Ruperti-Repilado FJ, Haefliger S, Rehm S, Zweier M, Rentsch KM, Blum J, Jetter A, Heim M, Leuppi-Taegtmeyer A, Terracciano L, Bernsmeier C. Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to Artemisia annua Tea. Front Med (Lausanne). 2019 Oct 11;6:221. doi: 10.3389/fmed.2019.00221. eCollection 2019
  • Bernsmeier C, De Gottardi A, Die Leberzirrhose ist nicht mehr die Leberzirrhose! Swiss Med Forum. 2018;18(5152):1090-1092.
  • Mensing B, Nowak A, Zweifel S, Terracciano L, Bernsmeier C, Filipowicz Sinnreich M. Morbus Wilson oder hepatolentikuläre Degeneration. Ther Umsch. 2018 Nov;75(4):241-248
  • Bernsmeier C, Triantafyllou E, Brenig R, Lebosse FJ, Singanayagam A, Patel VC, Pop OT, Khamri W, Nathwani R, Tidswell R, Weston CJ, Adams DH, Thursz MR, Wendon JA, Antoniades CG. CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair anti-microbial responses in patients with acute-on-chronic liver failure. Gut. Gut. 2018 Jun;67(6):1155-1167.
  • Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut. 2018 Feb;67(2):333-347.
  • Bernsmeier C. Die nicht-alkoholische Fettleber. Der informierte Arzt 2018; 01:15-17.
  • Bernsmeier C, Albano E, Liver dendritic cells and NAFLD evolution: A remaining open issue. J Hepatol. 2017 Jun;66(6):1120-1122.
  • Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. Increased Expression of CTLA4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Gastroenterology. 2017 Jul;153(1):263-276.e8.
  • Vergis N, Khamri W, Beale K, Sadiq F, Aletrari MO, Moore C, Atkinson SR, Bernsmeier C, Possamai LA, Petts G, Ryan JM, Abeles RD, James S, Foxton M, Hogan B, Foster GR, O'Brien AJ, Ma Y, Shawcross DL, Wendon JA, Antoniades CG, Thursz MR. Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase. Gut. 2017 Mar;66(3):519-529.
  • Bernsmeier C, Dill MT, Provenzano A, Makowska Z, Krol I, Muscogiuri G, Semela D, Tornillo L, Marra F, Heim MH, Duong FH. Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. Lab Invest. 2016 Sep;96(9):972-80.
  • Manakkat Vijay GK, Ryan JM, Abeles RD, Ramage S, Patel V, Bernsmeier C, Riva A, McPhail MJ, Tranah TH, Markwick LJ, Taylor NJ, Bernal W, Auzinger G, Willars C, Chokshi S, Wendon JA, Ma Y, Shawcross DL. Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure. Crit Care Med. 2016 Jan;44(1):43-53.
  • Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triatafyllou E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol. 2016 Jan;64(1):69-78.
  • Bernsmeier C, Singanayagam A, Patel VC, Wendon J, Antoniades CG. Immunotherapy in the treatment and prevention of infection in acute on chronic liver failure. Immunotherapy. 2015;7(6):641-54.
  • Bernsmeier C. Akute Dekompensation der Leberzirrhose und „acute-on-chronic“ Leberversagen. Leading Opinions Innere Medizin 2015; 6:84-87.
  • Bernsmeier C, Weisskopf DM, Pflueger MO, Mosimann J, Campana B, Terracciano L, Beglinger C, Heim MH, Cajochen C. Sleep Disruption and Daytime Sleepiness Correlating with Disease Severity and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: A Comparison with Healthy Controls. PLoS One. 2015 Nov 17;10(11):e0143293
  • Campana B, Semela D, Heim M, Bernsmeier C. Non-alcoholic fatty liver disease - changing the prevalence of liver cancer? EMJ Hepatol. 2015; 3(1):12-18.
  • Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J, Antoniades CG. Patients with Acute on Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK. Gastroenterology. 2015 Mar;148(3):603-615.
  • Balmer ML, Slack E, de Gottardi A, Lawson MA, Hapfelmeier S, Miele L, Grieco A, Van Vlierberghe H, Fahrner R, Patuto N, Bernsmeier C, Ronchi F, Wyss M, Stroka D, Dickgreber N, Heim MH, McCoy KD, Macpherson AJ. The liver may act as a firewall mediating mutualism between the host and its gut commensal microbiota. Sci Transl Med. 2014 May 21;6(237):237ra66.
  • Bernsmeier C, Antoniades CG, Wendon J. What's new in acute liver failure? Intensive Care Med. 2014 Oct;40(10):1545-8.
  • Bernsmeier C, Meyer-Gerspach AC, Blaser LS, Jeker L, Steinert RE, Heim MH, Beglinger C. Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic Fatty liver disease. PLoS One. 2014 Jan 29;9(1):e87488.
  • Bernsmeier C, Calabrese D, Heim MH, Duong HT. Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1. J Viral Hepat. 2014 Jan;21(1):9-18.
  • Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, O'Brien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M. Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure. Hepatology. 2014 Apr;59(4):1564-76.
  • Huber X, Droeser RA, Bernsmeier C, Kirchhoff P. When a colonoscopy becomes a duodenoscopy: a palliative treatment of a malignant sigmoidoduodenal fistula. BMJ Case Rep. 2013 May 24;2013. pii: bcr2012008241. doi: 10.1136/bcr-2012-008241.
  • Rosin C, Bernsmeier C, Entenza J, Moreillon P, Frei R, Weisser M, Flückiger U. Daptomycin for highly resistant Enterococcus faecium infection. Swiss Med Wkly. 2012;Jun 26;142:0
  • Bernsmeier C et Heim MH. Non-alcoholic fatty liver disease and steatohepatitis: Hepatic manifestations of the metabolic syndrome. Swiss Med Forum. 2011;11(4):53-57.
  • Bernsmeier C, Filipowicz M, Terracciano L, Duong F, Heim MH. S-Adenosyl-methionine and betaine improve early virological response in chronic hepatitis C patients with previous nonresponse. PLoS One. 2010;Nov 8;5(11):e15492.
  • Bernsmeier C, Nickel C, Bingisser R, Kim MJ. Urinary tract infection presenting with nonspecific complaints and normal urinalysis in 84-year-old woman. The American Journal of Case Reports, 2010; 11: 116-118
  • Osthoff M, Bernsmeier C, Marsch SC, Hunziker PR. Levosimendan as treatment option in severe verapamil intoxication: a case report and review of the literature. Case Report Med. 2010;2010. pii: 546904.
  • Bernsmeier C et Heim MH. Insulin Resistance in Chronic Hepatitis C: Mechanisms and Clinical Relevance. Swiss Med Wkly 2009;139(47-48):678-684.
  • Bernsmeier C, Duong F, Christen V, Pugnale P, Negro F, Terracciano L, Heim MH. Virus induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. J Hepatol. 2008;49(3):429-40.
  • Christen V, Duong F, Bernsmeier C, Sun D, Nassal M, Heim MH. Inhibition of alpha interferon signaling by hepatitis B virus. J Virol 2007;81:159-165.
  • von Wagner M, Huber M, Berg T, Hinrichsen H, Rasenack J, Heintges T, Bergk A, Bernsmeier C, Häussinger D, Herrmann E, Zeuzem S. Peginterferon-alpha-2a (40KD) and ribavirin for 16 or 24 weeks in patients with genotype 2 or 3 chronic hepatitis C. Gastroenterology 2005;129:522-527.