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Prof. Dr. med. Jan Hendrik Niess

Leitender Arzt Gastroenterologie/Hepatologie
Standort Universitätsspital Basel

 

Portrait
Portrait
Lebenslauf
Publikationen
Reviews
Lebenslauf

seit 2020
Klinischer Professor an der Medizinischen Fakultät der Universität Basel

seit 2019
Mitglied Klinikleitung / Leitender Arzt Gastroenterologie/Hepatologie, Clarunis Universitäres Bauchzentrum Basel/
Standort Universitätsspital Basel

10/2015
Tenure Track Assistant Professor for Gastroenterology, University of Basel

10/2012 – 09/215
Consultant in Gastroenterology and Research Group Leader, Inselspital, Bern

2012
Specialist in Gastroenterology

2010 - 2012
Endoscopy Service, Ulm University

2010
Board Examination Internal Medicine

2006 - 2010
Resident in Internal Medicine / Gastroenterology, Department of Internal Medicine I, Ulm University

2002 - 2006
Research Fellow, Massachusetts General Hospital and Harvard Medical School

2000 – 2002
Internship, Department in Internal Medicine, Charite, Berlin

2002
Medical Thesis Dr. med., Friedrich Schiller University Jena

1993 - 2000
Medical Studies Friedrich Schiller University Jena


 

 

Publikationen
  • Kaymak, T, Kaya B, Wuggenig P, Nuciforo S, Göldi A, Oswald F, Roux J, Noti M, Melhem H, Hrúz P, Niess JH: IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis. Gut, 2022.
  • Melhem H, Kaya , Kaymak T, Wuggenig P, Flint E, Roux J, Oost KC, Cavelti-Weder C, Balmer ML, Walser JC, Morales RA, Riedel CU, Liberali P, Villablanca EJ Niess JH: Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal Immunol, 2022. 15(3): p. 443-458.
  • Kaymak T, Hrúz P, Niess jH: Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases. Febs j, 2022. 289(16): p. 4758-4772.
  • Walldorf J, Porzner M, Neumann M, Joodi G, Niess JH, von Boyen G, Mader K, Weissbach J, Kleger A, Seufferlein T: The Selective 5-HT1A Agonist SR57746A Protects Intestinal Epithelial Cells and Enteric Glia Cells and Promotes Mucosal Recovery in Experimental Colitis. 2021: Inflamm Bowel Dis.
  • Sutter M, Hrúz P, Niess JH: High Serum Creatine Kinase Levels in Infliximab and Vedolizumab-Treated Inflammatory Bowel Disease Patients. 2021: Inflamm Intest Dis. 6: 165–174.
  • Rohm TV, Fuchs R, Muller RL, Keller L, Baumann Z, Bosch AJT, Schneider R, Labes D, Langer I, Pilz JB, Niess JH, Delko T, Hrúz P, Cavelti-Weder C: Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation. 2021: Front Immunol. 12: 668654.
  • Muller A, Bilger SS, Goldi A, Meinlschmidt G, Rueter F, Kappes A, Hrúz P, Meier CA, Niess JH: The IBD-Control questionnaire: German translation and validation of the standardized questionnaire for Patient Reported Outcome Measurement in inflammatory bowel disease. 2021: Z Gastroenterol.
  • Melhem H, Regan-Komito D, Niess JH: Mucins Dynamics in Physiological and Pathological Conditions. 2021: Int J Mol Sci 22.
  • Kaymak T, Hrúz P, Niess JH: Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases. 2021: FEBS J.
  • Kaya B, Melhem H, Niess JH: GPR35 in Intestinal Diseases: From Risk Gene to Function. 2021 Front Immunol. 12: 717392.
  • Katarina Radulovic, C. Korcan Ayata, Rachel Mak'Anyengo, Kristina Lechner, Philipp Wuggenig, Berna Kaya, Petr Hruz, Mercedes Gomez de Agüero, Petr Broz, Benno Weigmann and Jan Hendrik Niess. NLRP6-Deficiency in CD4 T cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol, DOI: https://doi.org/10.4049/jimmunol.1800938
  • Radulovic K, Mak‘Anyengo R, Ayata CK, Lechner K, Wuggenig P, Kaya B, Hruz P, Gomez de Agüero M, Broz P, Weigmann B, Niess JH. NLRP6-Deficiency in CD4 T cells Decreases T Cell Survival Associated with Increased Cell Death. J Immunol, in press.
  • Caviezel D, Maissen S, Niess JH, Kiss C, Hruz P. High Prevelance of Vitamin D Deficiency among Patients with Inflammatory Bowel Disease. Inflamm Intest Dis. 2018 Jul;2(4):200-210.
  • Kaymak T, Moriconi F, Niess JH, Beglinger C, Hruz P. Low Discontinuation Rate of Infliximab Treatment in Steroid-Dependent/Refractory Crohn`s Disease Patients. 2018 Mar;2(3):171-179.
  • Raduolovic K, Mak'Anyengo R, Kaya B, Steinert A, Niess JH. Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products after Intestinal Barrier Breach. J Vis Exp. 2018 May 2;(135).
  • Piñero P, Juanola O, Gutiérrez A, Zapater P, Giménez P, Steinert A, Sempere L, González-Navajas JM, Niess JH, Francés R. IL26 modulates cytokine response and anti-TNF consumption in Crohn`s disease patients with bacterial DNA. J Mol Med (Berl). 2017 Nov;95(11):1227-1236
  • Steinert A, Linas I, Kaya B, Ibrahim M, Schlitzer A, Hruz P, Radulovic K, Terracciano L, Macpherson AJ, Niess JH. The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bosel Disease Patients and in Colitis Models. J Immunol. 2017 Oct 1;199(7):2570-2584.
  • Dawson H, Novotny A, Becker K, Reim D, Langer R, Gullo I, Svrcek M, Niess JH, Tutuian R, Truninger K, Diamantis I, Blank A, Zlobec I, Riddell RH, Carneiro F, Fléjou JF, Genta RM, Lugli A. Macroscopy predicts tumor progression in gastric cancer: A retrospective patho-historical analysis based on Napoleon Bonaparte's autopsy report. Dig Liver Dis. 2016 Nov;48(11):1378-1385.
  • Rossini V, Radulovic K, Riedel CU, Niess JH. Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells. J Vis Exp. 2016 Sep 18;(115).
  • Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016 Oct;151(4):724-32.
  • Schulz, O., Ugur, M., Friedrichsen, M., Radulovic, K., Niess, J. H., Jalkanen, S., Krueger, A., Pabst, O. 2014. Hypertrophy of infected Peyer's patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress. Mucosal Immunol. 7(4):892-904.
  • Rossini, V., Zhurina, D., Radulovic, K., Manta, C., Walther, P., Riedel, C.U., Niess, J. H. 2014. CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis. Mucosal Immunol. 7(3):533-48.
  • Neu, C., Sedlag, A., Bayer, C., Förster, S., Crauwels, P., Niess, J. H., van Zandbergen, G., Frascaroli, G., Riedel, C. U. 2013. CD14-dependent monocyte isolation enhances phagocytosis of listeria monocytogenes by proinflammatory, GM-CSF-derived macrophages. PLoS One.11;8(6):e66898.
  • Radulovic, K., Rossini, V., Manta, C., Holzmann, K., Kestler, H. A., Niess, J. H. 2013. The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS One. 8(6):e65413.
  • Posovszky, C., Pfalzer, V., Lahr, G., Niess, J. H., Klaus, J., Mayer, B., Debatin, K. M., von Boyen, G. B. 2013 Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease. BMC Gastroenterol.13:77.
  • Manta, C., Heupel, E., Radulovic, K., Rossini V., Garbi, N., Riedel, C.U., Niess, J. H. 2013. CX3CR1+ Macrophages Support IL-22 Production by Innate Lymphoid Cells during Infection with Citrobacter rodentium. Mucosal Immunol. 6(1):177-88.
  • Schlitzer, A., Heiseke, A., Einwächter, H., Reindl, W., Schiemann, M., Manta, C., See, P., Niess, J. H., Suter, T., Ginhoux, F., Krug, A. B. 2012. Tissue-specific differentiation of a
  • circulating CCR9- pDC-like common dendritic cell precursor. Blood. 119(25):6063-71. IF 9.7759.7759.7759.7759.775
  • Grasedieck S., Schöler N., Bommer M., Niess J. H., Tumani H., Rouhi A., Bloehdorn J., Liebisch P., Mertens D., Döhner H., Buske C., Langer C., Kuchenbauer F. 2012. Impact of serum storage conditions on microRNA stability. Leukemia. Nov;26(11):2414-6.
  • Radulovic, K., Manta, C., Rossini, V.,Holzmann, K.H., Kestler, H.A., Wegenka, U.M., Nakayama, T., Niess, J.H. 2012. CD69 mediates type I interferon-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J Immunol. 188(4):2001-13.
  • Niess, J. H., Klaus, J., Pflüger, C., Degenkolb, N., Spaniol, U., Lahr, G, von Boyen, G. B. T. 2012. NOD2 polymorphism predicts response to treatment in Crohn´s disease, first steps to a personalized therapy. Dig Dis Sci. 57(4):879-86. IF 2.5502.5502.5502.5502.550
  • Schlitzer, A., Loschko, J., Mair K., Vogelmann, R., Henkel L., Einwaechter H., Schiemann, M., Niess, J.H., Reindl, W. and Krug. A. 2011. Identification of CCR9- plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood. 16;117(24):6562-70.
  • Diegelmann, J., Seiderer, J., Niess, J. H. , Haller, D., Göke, B., Reinecker, H. C. and Brand, S. 2010. Expression and regulation of the chemokine CXCL16 in Crohn’s disease and models of intestinal inflammation. Inflamm Bowel Dis. 16(11):1871-81.
  • Gronbach, K., Eberle, U., Ölschläger, T., Dobrindt, U., Leithauser, F., Niess, J. H., Döring, G., Reimann, J., Autenrieth, I. B., Frick, J. S. 2010. Safety of probiotic Escherichia coli strain Nissle 1917 depends on intestinal microbiota and adaptive immunity of the host. Infect Immun. 78:3036-46.
  • Preising, J., Philippe, D., Gleinser, M., Wei, H., Blum, S., Eikmanns, B. J., Niess, J. H., and Riedel, C.U. 2010. Selection of bifidobacteria for amelioration of murine colitis based on adhesion and anti-inflammatory capacity in vitro. Appl Environ Microbiol. 76(9):3048-51.
  • Niess, J. H. and Adler G. 2010. The Enteric Flora Selectively Expand Gut Lamina Propria CX3CR1+ Dendritic Cells Supporting Inflammatory Immune Responses under normal and inflammatory conditions. J Immunol. 15;184(4):2026-37.
  • Seiderer, J., J. Dambacher, D. Leistner, C. Tillack, J. Glas, Niess, J. H, , S. Pfennig, M. Jurgens, B. Muller-Myhsok, B. Goke, T. Ochsenkuhn, P. Lohse, H. C. Reinecker, and S. Brand. 2008. Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease. Clin Immunol 127:49-55.
  • Niess, J. H., F. Leithauser, G. Adler, and J. Reimann. 2008. Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions. J Immunol 180:559-568.
  • Salazar-Gonzalez, R. M.*, Niess, J. H. *, Zammit, D. J., Ravindran, R. , Srinivasan, A. , Maxwell, J. R, Stoklasek, T. , Yadav, R. , Williams, I. R. , Gu, X., McCormick, B. A., Pazos, M. A. , Vella, A. T., Lefrancois, L., Reinecker, H. C., McSorley, S. J. 2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 24:623-632 (*equally contributed).
  • Niess, J. H., S. Brand, X. Gu, L. Landsman, S. Jung, B. A. McCormick, J. M. Vyas, M. Boes, H. L. Ploegh, J. G. Fox, D. R. Littman, and H. C. Reinecker. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254-258.
  • Reich, M., J. H. Niess, C. Bar, G. Zwacka, and U. R. Markert. 2003. Elevated nonspecific plasma proteins in allergic patients. J Investig Allergol Clin Immunol 13:60-65.
  • Fatima, S., J. Ruter, J. H. Niess, B. F. Klapp, P. C. Arck, and M. Hildebrandt. 2003. CD26-/DPP IV-positive lymphocytes in murine acute experimental colitis. Adv Exp Med Biol 524:345-350.
  • J.-H. Niess Curriculum vitae and major achievements 6
  • Niess, J. H., C. Bar, G. Schlenvoigt, B. Fahlbusch, G. Zwacka, and U. R. Markert. 2002. IL-4 supplemented B-cell cultures of allergic children show reduced IgA and IgG production in response to additional stimulation with IL-10. J Investig Allergol Clin Immunol 12:99-106.
  • Neiss, J., J. Manuel, U. R. Markert, and D. A. Clark. 2000. Ly-49D transfected NK cells show reduced interleukin-10 production in response to H-2d and increased lytic activity: implication by interaction using class I MHC alloantigen+ target cells in pregnancy. Am J Reprod Immunol 44:47-51.
  • Markert, U. R., C. Bar, J. H. Niess, H. Vogelsang, and G. Zwacka. 1999. Elevated CD154 (CD40 ligand) synthesis in T-cells from allergic patients after nonspecific stimulation in vitro. J Investig Allergol Clin Immunol 9:248-252.
Reviews
  • Melhem H, Kaya B, Ayata KC, Hruz P, Niess JH. Metabolite-Sensing G Protein-Coupled Receptors Connect the Diet-Microbiota-Metabolites Axis to Inflammatory Bowel Disease. Cells, in press
  • Niess JH, Kaymak T, Hruz P. The Role of the Exposome in the Emergence of Chronic Inflammatory Bowel Diseases. Ther Umsch. 2019 Jan;75(5):261-270.
  • Niess JH, Hruz P, Kaymak T. The Interleukin-20 Cytokines in Intestinal Diseases. Front Immunol. 2018 Jun 18;9:1373.
  • Steinert A, Radulovic K, Niess J. Gastro-intestinal tract: The leading role of mucosal immunity. Swiss Med Wkly. 2016 Apr 5;146:w14293.
  • Radulovic K, Niess JH. CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment? J Immunol Res. 2015;2015:497056.
  • Niess, J. H., Danese, S. 2014. Anti-TNF and skin inflammation in IBD: a new paradox in gastroenterology? Gut. 63(4):533-5.
  • Stephani, J., Radulovic, K., Niess, J. H. 2011. Gut Microbiota, Probiotics and Inflammatory Bowel disease. Arch Immunol Ther Exp. 59(3):161-77.
  • Niess, J. H. 2010. What Are CX3CR1+ Mononuclear Cells in the Intestinal Mucosa? Gut Microbes. 1(6):396-400.
  • Niess, J. H. 2009. Role of gut-resident dendritic cells in inflammatory bowel disease. Expert Rev of Clin Immunol 5:451-461.
  • Niess, J. H. 2008. Role of mucosal dendritic cells in inflammatory bowel disease. World J Gastroenterol 14:5138-5148.
  • Niess, J. H., and H. C. Reinecker. 2006. Dendritic cells: the commanders-in-chief of mucosal immune defenses. Curr Opin Gastroenterol 22:354-360.
  • Niess, J. H., and H. C. Reinecker. 2006. Dendritic cells in the recognition of intestinal microbiota. Cell Microbiol 8:558-564.
  • Niess, J. H., and H. C. Reinecker. 2005. Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Curr Opin Gastroenterol 21:687-691.
  • Niess, J. H., H. Monnikes, A. U. Dignass, B. F. Klapp, and P. C. Arck. 2002. Review on the influence of stress on immune mediators, neuropeptides and hormones with relevance for inflammatory bowel disease. Digestion 65:131-140.