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Prof. Dr. med. Philipp Dutkowski

Leitender Arzt Viszeralchirurgie
Leiter Hepatobiliäre Chirurgie

 

Portrait
Portrait
Lebenslauf
Mitgliedschaften
Publikationen
Lebenslauf

Seit 2024                    
Leitender Arzt Viszeralchirurgie, Clarunis Universitäres Bauchzentrum Basel

Seit 2024
Leiter der Leber Transplantation, Universitätsspital Basel

2011-                                     
Professor für Chirurgie, Universität Zürich

2009-2023                                     
Leitender Arzt Klinik für Viszeral- und Transplantationschirurgie, Universitätsspital Zürich
Leiter der abdominalen Transplantationschirurgie, Universitätsspital Zürich

2004-2009
Oberarzt, Klinik für Viszeral- und Transplantationschirurgie, Universitätsspital Zürich

1999-2004
Oberarzt, Viszeralchirurgie, Universität Mainz

1993-1999
Assistenzarzt, Viszeralchirurgie, Universität Mainz

1991-1993
Assistenzarzt, Innere Medizin, Riedlingen, Universität Ulm

1985 - 1991
Medizinstudium, Universität Ulm, Deutschland

 

Mitgliedschaften
  • German Surgical Society (DGCH)
  • Swiss Transplant Society
  • European Surgical Association (ESA)
  • President STAL (Swiss Transplant Advisory group Liver transplant)
  • President STAPT (Swiss Transplant Advisory group Procurement)
  • Committee Medical Swiss Transplant
  • Special Interest Group ILTS Machine liver perfusion
Publikationen
  • Dutkowski P, Graf R, Clavien PA. Rescue of the cold preserved rat liver by hypothermic oxygenated machine perfusion. AJT 2006 May 6 (5): 903-912.
  • Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg 2006 Dec 244: 968-976.
  • de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, Clavien PA, Dutkowski P. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg 2009 Nov 250 (5):674-683.
  • Dutkowski P, Oberkofler CE, Slankamenac K, Puhan MA, Schadde E, Müllhaupt B, Geier A, Clavien P. Are there better guidelines for allocation in liver transplantation? A novel score targeting justice and utility in the model for end stage liver disease era. Ann Surg 2011 Nov 254: 745-753.
  • Dutkowski P, Schlegel A, Slankamenac K, Oberkofler CE, Adam R, Burroughs AK, Schadde E, Müllhaupt B, Clavien PA. The use of fatty liver grafts in modern allocation systems: risk assessment by the balance of risk (BAR) score. Ann Surg 2012 Nov 256: 861-868.
  • Schlegel A, de Rougemont O, Graf R, Clavien PA, Dutkowski P. Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts. J Hepatol 2013 Feb 58: 278-286.
  • Schlegel A, Graf R, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) protects from biliary injury in a rodent model of DCD liver transplantation. J Hepatol 2013 Nov 59: 984-991.
  • Dutkowski P, Schlegel A, de Oliveira M, Müllhaupt B, Neff F, Clavien PA. HOPE for human liver grafts obtained from donors after cardiac death. J Hepatol 2014 Apr 60(4):765-772.
  • Schlegel A, Kron P, Graf R, Dutkowski P*, Clavien PA*. Warm vs cold perfusion techniques to rescue rodent liver grafts. J Hepatol 2014 Dec 61(6):1267-1275.
  • Schlegel A, Kron P, Graf R, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) downregulates the immune response in a rat model of liver transplantation. Ann Surg 2014 Nov 260(5):931-937.
  • Dutkowski P, Polak WG, Muiesan P, Schlegel A, Verhoeven CJ, Scalera I, DeOliveira ML, Kron P, Clavien PA. First Comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: An international matched case analysis. Ann Surg 2015, Nov 262: 764-770.
  • Kron P, Schlegel A, de Rougemont O, Oberkofler CE, Clavien PA, Dutkowski P. Short, cool, and well oxygenated – HOPE for kidney transplantation in a rodent model. Ann Surg 2016 Nov 264(5):815-822.
  • Schlegel A, Linecker M, Kron P, Györi G, De Oliveira ML, Müllhaupt B, Clavien PA, Dutkowski P. Risk Assessment in high- and low– MELD liver transplantation. AJT 2017 17(4):1050-1063.
  • Kron P, Schlegel A, Mancina L, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion (HOPE) for fatty liver grafts in rats and humans. J Hepatol 2017 Sep 21: SO168-8278.
  • Muller X, Marcon F, Sapisochin G, Marquez M, Dondero F, Rayar M, Doyle MMB, Callans L, Li J, Nowak G, Allard MA, Jochmans I, Jacskon K, Beltrame MC, van Reeven M, Iesari S, Cucchetti A, Sharma H, Staiger RD, Raptis DA, Petrowsky H, de Oliveira M, Hernandez-Alejandro R, Pinna AD, Lerut J, Polak WG, de Santibañes E, de Santibañes M, Cameron AM, Pirenne J, Cherqui D, Adam RA, Ericzon BG, Nashan B, Olthoff K, Shaked A, Chapman WC, Boudjema K, Soubrane O, Paugam-Burtz C, Greig PD, Grant DR, Carvalheiro A, Muiesan P, Dutkowski P, Puhan M, Clavien PA. Defining Benchmarks in Liver transplantation: a multicenter outcome analysis determining best achievable results. Ann Surg 2018 Mar 267(3):419-425.
  • Schlegel A, Kalisvaart M, Scalera I, Laing RW, Mergental H, Mirza D, Perera T, Isaac J, Dutkowski P, Muiesan P. The UK DCD risk score: a new proposal to define futility in donation after circulatory death liver transplantation. 3 J Hepatol 2018 Mar 68(3):456-464.
  • Staiger RD, Cimino M, Javed A, Biondo S, Fondevila C, Perinel J, Aragao AC, Torzilli G, Wolfgang C, Adham M, Pinto-Marques H, Dutkowski P, Puhan MA, Clavien PA. The comprehensive complication index (CCI) is a novel cost assessment tool for surgical procedures. Ann Surg 2018 Nov 268(5):784-791.
  • Tschuor C, Ferrarese A, Kuemmerli C, Dutkowski P. Burra P, Clavien PA. Allocation of liver grafts worldwide-is there a best system? J Hepatol 2019 Oct 71(4):707-718.
  • Schlegel A, Muller X, Kalisvaart M, Muellhaupt B, Perera MTPR, Isaac JR, Clavien PA, Muiesan P, Dutkowski P. Outcomes of DCD liver transplantation using organs treated by hypothermic oxygenated perfusion before implantation. J Hepatol 2019 Jan 70(1):50-57.
  • Muller X, Schlegel A, Kron P, Eshmuminov D, Würdinger M, Meierhofer D, Clavien PA, Dutkowski P. Novel real-time prediction of liver graft function during hypothermic oxygenated machine perfusion before transplantation. Ann Surg 2019 270(5):783-790.
  • Kron P, Schlegel A, Muller X, Gaspert A, Clavien PA, Dutkowski P. Hypothermic oxygenated perfusion: a simple and effective method to modulate the immune response in kidney transplantation. Transplantation 2019 May 103(5):128-136.
  • Eshmuminov D, Becker D, Bautista Borrego L, Hefti M, Schuler MJ, Hagedorn C, Muller X, Mueller M, Onder C, Graf R, Weber A, Dutkowski P, Rudolf von Rohr P, Clavien PA. An integrated perfusion machine preserves injured human livers for 1 week. Nature Biotechnol 2020 Feb (28(2):189-198.
  • Darius T, Vergauwen M, Smith T, Gerin I, Joris V, Mueller M, Aydin S, Muller X, Schlegel A, Nath J, Ludwig C, Dessy C, Many MC, Bommer G, Dutkowski P, Gianello P, Moutad M. Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model. AJT 2020 Aug 20(8):2030-2043.
  • Mueller M, Kalisvaart M, O Rourke J, Shetty S, Parente A, Muller X, Isaac J, Muellhaupt B, Muiesan P, Shah T, Clavien PA, Schlegel A, Dutkowski P. Hypothermic oxygenated liver perfusion (HOPE) prevents tumor recurrence in liver transplantation from donation after circulatory death. Ann Surg 2020, 272(5):759-765.
  • Ignatavicius P, Oberkofler CE, Chapman WC, DeMatteo RP, Clary BM, D Angelica MI, Tanabe KK, Hong JC, Aloia TA, Pawlik TM, Henandez-Alejandro R, Shah SA, Vauthey JN, Torzilli G, Lang H, Line PD, Soubrane O, Pinto-Arques H, Robles-Campos R, Boudema K, Lodge P, Adam R, Toso C, Serrablo A, Aldrighetti L, DeOliveira ML, Dutkowski P, Petrowsky H, Linecker M, Reiner CS, Brain J, Alikhanov X, De Santibanes E, Mercado MA, Andriani OC, Torres OJM, Pinna AD, Clavien PA.Choices of therapeutic strategies for colorectal metastases among expert liver surgeons: A throw of the dice? Ann Surg 2020, 272(5):715-722.
  • Müller X, Mohkam K, Mueller M, Schlegel A, Dondero F, Sepulveda A, Savier E, Scatton O, Bucur P, Salame E, Jeddou H, Sulpice L, Pittau G, Allard MA, Mabrut JY, Dutkowski P*, Clavien PA*, Lesurtel M*. Hypothermic oxygenated perfusion versus normothermic regional perfusion in liver transplantation from controlled donation after circulatory death: First international comparative study. Ann Surg 2020, 272(5):751-758. 27.
  • Oberkofler CE, Raptis DA, DiNorcia J, Kaldas FM, Müller PC, Pita A, Genyk Y, Schlegel A, Muiesan P, Tun Abraham ME, Dokus K, Hernandez-Alejandro R, Rayar M, Boudjema K, Mohkam K, Lesurtel M, Esser H, Maglione M, Vijayanand D, Lodge JPA, Owen T, Malagó M, Mittler J, Lang H, Khajeh E, Mehrabi A, Ravaioli M, Pinna AD, Dutkowski P, Clavien PA, Busuttil RW, Petrowsky H. How to handle arterial conduits in liver transplantation? Evidence form the first multicenter risk analysis. Ann Surg. 2020 Jan 16. doi: 10.1097/SLA.0000000000003753.
  • Schlegel A, Müller X, Mueller M, Stepanova A, Kron P, De Rougemont O, Muiesan P, Clavien PA; Galkin A, Meierhofer D, Dutkowski P. Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation. EBioMedicine 2020 Oct;60:103014. doi: 10.1016/j.ebiom.2020.103014. Epub 2020 Sep 24.
  • Wyss RK, Mendez Carmona N, Arnold M, Segider A, Mueller M, Dutkowski P, Carrel TP, Longnus SL. Hypothermic oxygenated perfusion (HOPE) provides cardiopreotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD). AJT 2021 Mar 21(3):1003-1011.
  • Mueller M, Hefti M, Eshmuminov D, Schuler MJ, Sousa Da Silva RX, Petrowsky H, Oliveira ML, Oberkofler CE, Hagedorn C, Mancina L, Weber A, Burg B, Tibbit MW, Rudolf von Rohr P, Dutkowski P, Becher D, Baustista 4 Borrego L, Clavien PA. Long-term normothermic machine preservation of partial livers: First experience with 21 human hemi-livers. Ann Surg 2021,Jul 29. doi: 10.1097/SLA.0000000000005102.
  • Eden J, Sousa da Silva R, Cortes-Cerisuelo M, Croome K, et al. Utilization of livers donated after circulatory death for transplantation – An international comparison. J Hepatol 2023, 78(5): 1007-1016. II. Reviews (selected): cumulative impact 276,3 mean impact 27.6
  • Dutkowski P, de Rougemont O, Clavien PA. Machine perfusion for marginal liver grafts. AJT 2008 May 8:917-924 2.
  • Dutkowski P, De Rougemont O, Müllhaupt B, Clavien PA. Current and future trends for liver transplantation in Europe. Gastroenterology 2010 Mar 138: 802-809.
  • McCormack L, Dutkowski P, El-Badry AM, Clavien PA. Liver transplantation using fatty livers: always feasible? J Hepatol 2011, May 54: 1055-1062.
  • Dutkowski P, Linecker M, DeOliveira ML, Müllhaupt B, Clavien PA. Challenges to liver transplantation and strategies to improve outcomes. Gastroenterology 2015 Feb 148:307-323.
  • Clavien PA, Muller X, de Oliveira ML, Dutkowski P, Sanchez-Fueyo A. Can immunosuppression been stopped after liver transplantation? Lancet Gastroenterol Hepatol 2017 Jul 2(7):531-537.
  • Linecker M, Krones T, Berg T, Niemann CU, Steadman RH, Dutkowski P, Clavien PA, Busuttil RW, Truog RD, Petrowsky H. Potentially inappropriate liver transplantation in the era of the sickest first policy a search for the upper limits. J Hepatol 2018 Apr 68: 798-813. 7. Schlegel A, Dutkowski P. Impact of machine perfusion on biliary complications after liver transplantation. Int J Mol Sci. 2018 Nov 12;19(11):3567. doi: 10.3390/ijms19113567 8. Schlegel A, Muller X, Dutkowski P. Machine perfusion strategies in liver transplantation. Hepatobiliary Surg Nutr 2019 Oct 8: 490-501. 9. Dutkowski P, Guarrera JV, de Jonge J, Martins PN, Porte RJ, Clavien PA. Evolving trends in machine perfusion for liver transplantation. Gastroenterology 2019 May 156:542-1647.
  • Petrowsky H, Fritsch R, Guckenberger M, De Oliveira ML, Dutkowski P, Clavien PA. Modern therapeutic approaches in the treatment of malignant liver tumors. Nature Rev Gastroenterol Hepatol 2020 Dec: 755-772. C.